- A-SPEC stands for A System Specification
- ASPEC stands for Academy of Senior Professionals at Eckerd College
- ASPEC stands for Adaptive Spectral Perceptual Entropy Coding (audio data compression)
- ASPEC stands for Advanced Spectre Entropy Coding (MPEG)
- ASPEC stands for Alzheimer Society of Prince Edward County (Canada)
- ASPEC stands for Asia Pacific Environmental Consultants Sdn. Bhd. (Malaysia)
- A-SPEC stands for A-Specification
- ASPEC stands for Association pour la Prévention et l’Etude de la Contamination (French: Association for the Study and Prevention of Contamination; est. 1971)
- ASPEC stands for Automated Solid Phase Extraction Controller (pharmaceutical research)
- ASPEC stands for Automatic Sample Preparation with Extraction Column
- A-SPEC stands for System Specification
A-SPEC