- D2R stands for Dance Dance Revolution (game aka DDR)
- D2R stands for Degrees to Radians (mathematics measurement conversion)
- D2R stands for Dreams to Reality (various organizations)
- D2R stands for Direct-to-Retail (distribution model)
- D2R stands for Door-to-Reperfusion (cardiology)
- D2R stands for Digital-to-the-Room (entertainment product)
- D2R stands for From Discovery to Recovery (lecture series)
D2R