- C2D stands for Core 2 Duo (Intel processor)
- C2D stands for Contrat de Désendettement et de Développement (French: Contract of Debt Reduction and Development)
- C2D stands for Click to Download
- C2D stands for Crash to Desktop (software malfunction)
- C2D stands for Concept to Design (various organizations)
- C2D stands for Committed to Diversity (task force; Oregon State University)
- C2D stands for Command and Control Directorate (US Army CECOM)
- C2D stands for Close 2 Death (gaming community)
- C2D stands for Connect to Decode (tuberculosis genome mapping project)
- C2D stands for Close 2 Death Recordings (UK Record Label)
C2D