- DIRS stands for Disaster Information Reporting System (web-based communications system)
- DIRS stands for Directional Survey Log (energy production)
- DIRS stands for Digital Imaging and Remote Sensing (various organizations)
- DIRS stands for Développement Intégré de la Région du Sanmatenga (French: Integrated Development Region Sanmatenga, Burkina Faso)
- DIRS stands for Dynamic Intrusion Response System (Enterasys)
- DIRS stands for Damage Information Recording System
- DIRS stands for Decomplemented Isologous Rat Serum
- DIRS stands for Digital Image Rectification System
DIRS