- ACME stands for Action Coalition for Media Education (Albuquerque, NM)
- ACME stands for Advisory Committee on Mathematics Education
- ACME stands for Automatic Certificate Management Environment (communications protocol)
- ACME stands for Arms Control in the Middle East (talks; various nations)
- ACME stands for Association for Convention Marketing Executives
- ACME stands for Aerospace, Civil and Mechanical Engineering (department)
- ACME stands for Advisory Committee on the Marine Environment
- ACME stands for Association of Consulting Management Engineers
- ACME stands for Assembling Configuration Management Environments (software development)
- ACME stands for Application of Commercially Manufactured Electronics
- ACME stands for Advanced Cosmic Microwave Explorer (satellite)
- ACME stands for Adaptive Collection Management Environment
- ACME stands for Applications of Computers to Manufacturing Engineering
- ACME stands for Alumni Council of Middle East
- ACME stands for Annual Conference of Managing Editors
- ACME stands for Actively Conserving Marysville Environs
- ACME stands for Air Crew Combat Mission Enhancement
- ACME stands for Automated Contractual Minimal Enhancements (Sprint)
- ACME stands for Airborne Cloud Measurement Equipment
- ACME stands for Authentication Credential Management Extension (authentication subsystem, OpenVMS HP Corporation)
ACME