- ACSL stands for Advanced Continuous Simulation Language (AEgis Technologies Group, Inc.)
- ACSL stands for American Computer Science League
- ACSL stands for Assistant Cub Scout Leader
- ACSL stands for Altocumulus Standing Lenticular Clouds (often confused for UFOs)
- ACSL stands for Alternate Crops and Systems Laboratory
- ACSL stands for Abrams Common Software Library (US Army)
- ACSL stands for Association Control Service Element
- ACSL stands for Asociación de Caridad San Lucas (San Lucas, Guatemala Association of Charity)
- ACSL stands for Advanced Chemical Science Laboratory (US National Institute of Standards and Technology)
- ACSL stands for Asian CounterStrike Source League (gaming)
- ACSL stands for Analytical Chemistry Services Laboratory
ACSL