- DRSI stands for Diabetica Research Solutions, Inc. (Boca Raton, FL)
- DRSI stands for Delta Rural Systemic Initiative (science and mathematics education)
- DRSI stands for Département Réseaux et Serveurs d’Information (French: Department of Information Networking and Servers; Algeria)
- DRSI stands for Destination Station Routing Indicator
- DRSI stands for Digital Reasoning Systems, Inc. (Brentwood, TN)
- DRSI stands for Développement et Réseau des Systèmes Informatiques (French: Network Development and Information Systems)
- DRSI stands for Danella Rental Systems, Inc. (Plymouth Meeting, PA)
- DRSI stands for Designed Receivable Solutions, Inc.
DRSI