- AFOS stands for A Flock of Seagulls (band)
- AFOS stands for Automation of Field Operations and Services
- AFOS stands for Antarctic Fibre Optic Spectrometer
- AFOS stands for Air Force Operation Service
- AFOS stands for Application for Order for Sale (real property)
- AFOS stands for Auxiliary Fuel Oil System
- AFOS stands for Assault Follow-On Shipping
- AFOS stands for Anterior Fontanelle Open and Soft
AFOS