- AFX stands for Aphex Twin (musician)
- AFX stands for Action Figure Xpress (online shop)
- AFX stands for Animation Framework Extension (IEEE)
- AFX stands for Atypical Fibroxanthoma (a malignant or benign neoplasm of the connective tissue)
- AFX stands for Application Frameworks (Microsoft Foundation Class)
- AFX stands for Air-Fluid Exchange
- AFX stands for Agence France/Extel Financial (financial news arm of Agence France-Presse)
AFX