- ACSC stands for Automobile Club of Southern California (AAA)
- ACSC stands for Area of Critical State Concern (Florida)
- ACSC stands for Australian Computer Science Conference
- ACSC stands for Ambulatory Care Sensitive Condition
- ACSC stands for Air Command & Staff College
- ACSC stands for Association of Carolina Shag Clubs
- ACSC stands for Advanced Casino Systems Corporation (Bally Gaming and Systems)
- ACSC stands for Australian Centre for Sustainable Catchments
- ACSC stands for Armament Cooperation Steering Committees (US DoD)
- ACSC stands for American Society of Corporate Secretaries
- ACSC stands for Asociación Colombiana de Sociedades Científicas (Colombian Association of Scientific Societies)
- ACSC stands for Aegis Combat Systems Center (Wallops Island, VA)
- ACSC stands for Association of Casualty and Surety Companies (now American Insurance Association)
- ACSC stands for Australia Commonwealth Specialist Catalogue (philatelic catalog)
- ACSC stands for American Council on Schools & Colleges
- ACSC stands for APMO Customer Support Center
- ACSC stands for Afghan Community Services Center
ACSC