- AFAM stands for American Folk Art Museum (New York)
- AFAM stands for Almost Family (est. 1976)
- AFAM stands for Alta Formazione Artistica e Musicale (Italian: Higher Education in Art and Music)
- AFAM stands for Atomic Force Acoustic Microscopy (imaging)
- AFAM stands for Air Force Achievement Medal
- AFAM stands for Air Force Acquisition Model (early US DoD Acquisition Deskbook)
- AFAM stands for African American Civil War Memorial (US National Park Service)
- AFAM stands for Advanced Fresh Air Management (refrigeration; Thermo King)
- AFAM stands for Ancient Free and Accepted Mason
- AFAM stands for ATRRS Funding Allocation Model
- AFAM stands for Advanced Field Artillery Model
AFAM