- AFDS stands for Associazione Friulana Donatori di Sangue (Italian blood donors association)
- AFDS stands for Automatic Flight Director System
- AFDS stands for Autopilot Flight Director System
- AFDS stands for Air Force Digital Service (US Air Force)
- AFDS stands for Autonomous Free-flight Dispenser System
- AFDS stands for Amphibious Flagship Data System
- AFDS stands for Automatic Fire Detection System
- AFDS stands for Air Force Directory Service
- AFDS stands for Aboriginal Front Door Society (Canada)
- AFDS stands for Automated Fuel Data System (Canada)
- AFDS stands for Alternative Financing and Delivery System (healthcare)
AFDS