- AFFIRM stands for Atrial Fibrillation Follow-Up Investigation of Rhythm Management (heart rhythm study)
- AFFIRM stands for Association For Federal Information Resources Management
- AFFIRM stands for Alliance for Fair Federal Immigration Reform of Minnesota (est. 2001)
- AFFIRM stands for Alliance for Fairness in Reforms to Medicaid (Washington, DC)
- AFFIRM stands for Alberta Farm Fertilizer Information and Recommendation Manager (software; Alberta, Canada)
AFFIRM