- AFK Away From Keyboard
- AFK stands for Afkorting (Dutch: abbreviation)
- AFK stands for Afrikaans (SIL code)
- AFK stands for All for Kill (gaming)
- AFK stands for Aus- und Fortbildungs Gmbh für Elektronische Medien
- AFK stands for Austriackie Forum Kultury (Polish: Austrian Cultural Forum; Warsaw, Poland)
- AFK stands for Anderson Flesher and Key (band)
- AFK stands for Allerød Fodbold Klub (Danish: Allerød Football Club; Allerød, Denmark)
- AFK stands for A Free Kill (gaming)
- AFK stands for Anadolu Finans Kurumu (Anadolu Finance House)
- AFK stands for Aarhus Fridykkerklub (Denmark)
- AFK stands for Absolute Frequency Keying
- AFK stands for Africaans/Afrikaans
- AFK stands for Always Frisky Kerrans (gaming)
AFK