- C-SAFE stands for Consortium for Southern Africa Food Security Emergency
- CSAFE stands for Collaborative Supervision and Focused Enforcement (Baltimore, MD)
- CSAFE stands for Centre for the Study of Agriculture, Food and Environment (University of Otago; Dunedin, New Zealand)
- C-SAFE stands for Cyber Security Awareness for Everyone
- C-SAFE stands for Center for the Simulation of Accidental Fires & Explosions (University of Utah)
- CSAFE stands for Communications Specification for Fitness Equipment
C-SAFE