- C2R stands for Click to Run (software)
- C2R stands for Concept to Reality (biannual magazine; Altair Engineering, Inc.)
- C2R stands for Complex to Real (data output)
- C2R stands for Colleagues Committed to Redesign
- C2R stands for Command and Control Registry
- C2R stands for Committed to Redesign Program (Rensselaer Polytechnic Institute; Troy, NY)
- C2R stands for Consumer to Retailer
C2R