- D&D stands for Design & Development
- D&D stands for Dungeons and Dragons
- D&D stands for Dean & Deluca
- D&D stands for Drag and Drop (mouse interface)
- D&D stands for Dumb and Dumber (movie)
- D&D stands for Deaf and Dumb
- D&D stands for Deities and Demigods
- D&D stands for Denial and Deception (US DoD)
- D&D stands for Deuterium Deuterium
- D&D stands for Decontamination and Decommissioning
- D&D stands for Death & Disability (insurance coverage)
- D&D stands for Death and Dismemberment
- D&D stands for Drunk and Disorderly
- D&D stands for Drug and Disease
- D&D stands for Dishwasher and Disposal
- D&D stands for Done and Dusted
- D&D stands for Deactivation and Decommissioning
- D&D stands for Detection and Direction
- D&D stands for Delay and Disruption
- D&D stands for Degen & Degen Architecture and Interior Design (various locations)
- D&D stands for Damage & Destroy
- D&D stands for Distress and Diversion
- D&D stands for Devon shire and Dorset Regiment (British regiment)
- D&D stands for Divorced & Desperate
- D&D stands for Diversity and Dialogue (Norway and UK)
- D&D stands for Display & Decision (Area)
- D&D stands for Divestiture & Deregulation
- D&D stands for Distress & Disaster
- D&D stands for Diu and Damman (India)
D&D