- DPLS stands for Data and Program Library Service (University of Wisconsin-Madison)
- DPLS stands for Defiance Public Library System (Defiance, OH)
- DPLS stands for Deschutes Public Library System (est. 1920; Deschutes, OR)
- DPLS stands for Dakota Plains Legal Services
- DPLS stands for Discriminant Partial Least Square
- DPLS stands for Digital Private Line Service (WorldCom)
- DPLS stands for Dynamic Perfusory Lung Scintigraphy
DPLS