- DREF stands for Disaster Relief Emergency Fund (International Red Cross/Red Crescent)
- DREF stands for Direction des Ressources Éducatives Françaises (French: French Learning Resources Branch; Canada)
- DREF stands for Distribution Research and Education Foundation
- DREF stands for Delta Research and Educational Foundation (Washington, DC)
- DREF stands for Dose-Rate Effectiveness Factor
- DREF stands for DNA Replication-Related Element Binding Factor
- DREF stands for Dynamic Real Estate Fund (Switzerland)
DREF