- DRU stands for Druid (Everquest)
- DRU stands for Dezvoltarea Resurselor Umane (Romanian: Human Resources Development)
- DRU stands for Doctoral/Research University (school classification)
- DRU stands for Disaster Resistant University
- DRU stands for Direct Reporting Unit
- DRU stands for Disaster Response Unit (various organizations)
- DRU stands for Direct Response Unit (INMARSAT)
- DRU stands for Dynamic Reference Unit
- DRU stands for Diplôme de Recherche Universitaire (French: University Research Degree)
- DRU stands for Differential Rate Unit (energy measurement)
- DRU stands for Digital Radio Unit
- DRU stands for Da Roxor United (gaming clan)
- DRU stands for Data Recovery Unit
- DRU stands for Dansk Rugby Union (Danish Rugby Club)
- DRU stands for Development Review Unit (various locations)
- DRU stands for Demolition Research Unit (US Navy)
- DRU stands for Desert Research Unit
- DRU stands for Distal Radio-Ulnar
- DRU stands for Data Retrieval Unit
- DRU stands for Data Receiver Unit
- DRU stands for Data Reformatter Unit
- DRU stands for Depot Replaceable Unit
- DRU stands for Demountable Refrigeration Unit
- DRU stands for Double Radio Unit
DRU