- DS2 stands for Dark Souls 2 (gaming)
- DS2 stands for Dead Space 2 (gaming)
- DS2 stands for Dualshock 2 (gamepads)
- DS2 stands for Dungeon Siege 2 (video game)
- DS2 stands for Design of Systems on Silicon
- DS2 stands for Defense Support Services (Lockheed Martin/Day Zimmermann)
- DS2 stands for Deca Sports 2 (game)
- DS-2 stands for Digital Signal, Level 2 (6.176 Mbit/s, DS1 x 4 mux)
- DS2 stands for Digital Signal 2 – (6.54 Mbps Pipe)
- DS2 stands for Decontamination Solution Number Two
- DS-2 stands for Decontamination Solution 2
- DS2 stands for Data Systems Technician Second Class (US Navy Rating)
- DS-2 stands for Drosophila Melanogaster Schneider-2
- DS2 stands for Second Version of the Duman-Salehi Bound
DS-2