- DSSI stands for Diplôme en Sécurité des Systèmes d’Information (French: Diploma in Information Systems Security; Switzerland)
- DSSI stands for Disposable Soft Synth Interface (software)
- DSSI stands for Diversified Scientific Services, Inc.
- DSSI stands for Digital Storage Systems Interconnect
- DSSI stands for Data Systems and Software Inc. (Mahwah, NJ)
- DSSI stands for Dyspepsia Symptom Severity Index
- DSSI stands for Dead Sea Scrolls Institute (Trinity Western University, Canada)
- DSSI stands for Directions de la Sécurité des Systèmes d’Information (French: Information Systems Security Directorate)
- DSSI stands for Deep Surgical Site Infection
DSSI