- YDB stands for Younger Dryas Boundary (hypothesis)
- YDB stands for Yucky Discolored Box Syndrome (Adobe InDesign problem)
- YDB stands for Yokohama Dena Baystars (Japanese baseball team)
- YDB stands for You Deserve Better
- YDB stands for Yeah da Boys
- YDB stands for Youth Design Boston (summer internship and mentoring program; Boston, MA)
- YDB stands for You Dumb Bastard
- YDB stands for Yeast Dextrose Broth (microbiology)
- YDB stands for Yeat da Bun (commonly used in the town of Newburyport, MA)
- YDB stands for Yield Difference Bonding
YDB