- ZLS stands for Zimmermann-Laband Syndrome
- ZLS stands for Zion Lutheran School (various locations)
- ZLS stands for Zero Length String (programming value)
- ZLS stands for Zeeman Laser Scattering
- ZLS stands for Zambia Library Service (est. 1962; Ministry of Education)
- ZLS stands for Zanzibar Law Society (Tanzania)
- ZLS stands for Zero-Lifetime Space (programming)
ZLS