- AFCF stands for Advanced Fuel Cycle Facility (DOE project at Idaho National Lab)
- AFCF stands for Association des Femmes Chefs de Famille (French: Association of Women Heads of Family; Mauritania)
- AFCF stands for After Former Conviction of a Felony (criminal law)
- AFCF stands for Antibody-Forming Cell Focus (molecular biology)
AFCF