- AFDC stands for Aid to Families with Dependent Children
- AFDC stands for Alternative Fuels Data Center
- AFDC stands for Atlanta Flying Disc Club (Atlanta, GA)
- AFDC stands for Autopilot Flight Director Computer (avionics)
- AFDC stands for Air Force Doctrine Center
- AFDC stands for Allowance for Funds During Construction
- AFDC stands for Asia-Pacific Finance and Development Center
- AFDC stands for Association des Familles de Disparus de Constantine (French: Association of Families of the Disappeared in Constantine; Constantine, Algeria)
- AFDC stands for Axial Flux Difference
AFDC