- AFFM stands for Adoptive and Foster Families of Maine (Old Town, Maine)
- AFFM stands for Aviation and Forest Fire Management (Canada)
- AFFM stands for Australian Federation of Friends of Museums (Australia)
- AFFM stands for Adaptive Fuzzy Feature Map (data mining)
- AFFM stands for Atomic Force Fluorescence Microscope (biophotonics)
- AFFM stands for Air Force Family Matters
AFFM