- AFOC stands for Association Force Ouvrière Consommateurs (French consumer organization)
- AFOC stands for Air Force Operations Center
- AFOC stands for Asian Fight against Oral Cancer (est. 1993)
- AFOC stands for Alaska Field Operations Center
- AFOC stands for Anchorage Fracture and Orthopedic Clinic (Alaska)
- AFOC stands for Air Force Opportunity Center
- AFOC stands for Army Flight Operations Center (US Army)
AFOC