Posted in Internet Slang, Organizations DUFF stands for Dumb Ugly Fat Friend DUFF stands for Down Under Fan Fund DUFF stands for Denver Underground Film Festival (Colorado) DUFF stands for Designated Ugly Fat Friend DUFF Share Pinterest Tweet Whatsapp Post navigation DUFFADUFE Leave a Reply Cancel replyYour email address will not be published. Required fields are marked *Comment * Name * Email * Website Save my name, email, and website in this browser for the next time I comment.